Monday, August 6, 2012

Six Questions with Dr. Jeffrey Niezgoda

President, American College of Hyperbaric Medicine (ACHM) 
Medical Director, The Center for Comprehensive Wound Care and Hyperbaric Oxygen Therapy, St. Luke's Medical Center, Aurora Health Care, Milwaukee, Wisconsin    
President and Chief Medical Officer of WebCME.net   
Associate Professor and Hyperbaric Consultant, Medical College of Wisconsin 
MD from the Uniformed Services University of the Health Sciences, F. Edward Hebert School of Medicine, Bethesda, Maryland, 1985    
BS in Biology from the US Air Force Academy, Colorado Springs, Colorado, 1981


Jeffrey A. Niezgoda, MD, FACHM, MAPWCA, is a recognized wound care and hyperbaric medicine expert, educator, and entrepreneur. We know him best as president of the American College of Hyperbaric Medicine (ACHM), a professional organization working to develop an image of hyperbaric oxygen therapy as a distinct medical specialty, often requiring full-time practice. His work uniquely spans the clinical, professional, academic, and business aspects of hyperbaric medicine today. He spoke with us in his Milwaukee offices in March 2012.

1.
HyperbaricLink: Tell us about the first time you ever saw a hyperbaric chamber.
Niezgoda: My first exposure to hyperbaric medicine was many years ago, circa 1976. I grew up here in Milwaukee and had the privilege of touring St. Luke’s and the hyperbaric unit when I was an Explorer Scout. I was 17 or 18 years old at the time, and I joined a medical explorer post, because I wanted to go into medicine. Ironically, the hyperbaric chamber tour was conducted by Dr. Eric Kindwall, who many years later became my colleague and mentor, and a dear friend. I clearly remember him showing us the original multiplace chambers, Bonnie and Clyde. I’m very sad that he’s no longer with us. I often think back to that day that I first met Dr. Kindwall, at the time never dreaming of walking in his footsteps. It is amazing to me that I have been so fortunate to have had the honor and privilege to come back to Milwaukee to practice hyperbaric medicine.

2.
HyperbaricLink: Can you a recall one real breakthrough success or aha! moment in your career?
Niezgoda: Yes, it was when I was doing my fellowship at Travis Air Force Base, in the late 1980s, working with another one of the world renowned hyperbaric physicians, Dr. Ben Slade. I was still learning and questioning certain aspects of hyperbaric medicine, in a way trying to validate it in my own mind. Much of our time was dedicated to treating the standard conditions. But Ben always liked to push the envelope, and use HBO to help patients that presented with problems that theoretically would benefit from hyperbaric. So from time to time we would treat conditions that were considered experimental back then, under IRB [institutional review board] guidance, of course. Sometimes the patients improved, sometimes not. One day Dr. Slade came in to Morning Report and said, “We’re going to start treating a patient with brain abscess.” I was thinking to myself, “You've got to be kidding! Here we go again.” The patient was actually incarcerated at the prison in nearby Vacaville, California. Every day two armed guards brought the prisoner in from the infirmary, by ambulance, on a gurney, dressed in his orange garb. I thought that the handcuffs and guards were somewhat silly as the patient was essentially comatose due to high intracranial pressure and mass effect from several large abscesses. He was obtunded and didn’t know who he was or where he was. He had been on broad-spectrum antibiotics for several days and really wasn't getting any better. The neurosurgeon who referred the patient to us said, “If I open this patient’s cranium to drain the abscess, he will end up herniating and dying.” So this is how it went day after day. The patient would come in for treatment, we would say hello and he would not respond in any way. Well, I’ll never forget it. On hyperbaric day 7 or 8, I was sitting with my back to the door, charting. Klaus, my med tech, came in and said, “Dr. Niezgoda, Mr. XYZ is here for his treatment.” Very facetiously, without looking up, I said, “Great! Let the party begin!” All of a sudden I hear a voice I didn't recognize say, “I’ll bring the women and the beer!” I turned around and see this guy is sitting up in his gurney, fully awake, fully conversant, sharp as can be. It was simply amazing.

3.
HyperbaricLink: How would you characterize the status of hyperbaric oxygen in healthcare today?
Niezgoda: The overall acceptance and validation of hyperbaric medicine as a true medical specialty is probably the biggest change that has happened over the last 5 to 10 years. When I was doing my fellowship we had to really work for patient referrals. There were a lot of naysayers. There was a lot of skepticism. We were criticized for the lack of hyperbaric literature. We worked hard to convince our colleagues that HBO was a valid adjunctive treatment. It often felt like I had to be a cheerleader or salesman for this treatment modality. Fortunately for our patients, much of this has changed. Some really excellent clinical and research studies with supporting publications have appeared in the literature. Based on the literature and excellent clinical outcomes, hyperbaric has truly emerged as a primary advanced treatment modality for wound care patients. Younger doctors appear more ready to accept case studies which highlight some really amazing success stories and refer their patients for care. I think mainstream medicine has finally accepted hyperbaric as a viable treatment. It is rewarding after all these years of hard work, advocating for a treatment that I believe in based on outstanding results and limb salvage, to have physicians who had previously doubted and questioned hyperbaric—the plastic surgeons, the vascular surgeons, the general surgeons—now calling and asking for our help.

4.
HyperbaricLink: What can the hyperbaric community do to better educate the public and referring physicians?
Niezgoda: I don't think that, as hyperbaric physicians, we like to boast or wave our flag. I think we do a great job of providing care. I think we do a great job of taking care of patients. However, we don’t do a very good job of telling our success stories. We have wonderful success stories, great outcomes, and amazing stories to tell about healing. Unfortunately, this information does not get shared very well. We need to tell the world what a huge impact we make in people’s lives. When a young child nearly drowns and is resuscitated and has a great outcome, the media praise the medical community. It makes the news headlines. Limb salvage, necrotizing fasciitis, and carbon monoxide cases, quite frankly, can be just as impressive. Sure, patients go out and talk about it. But if you try to market anything in the US by word-of-mouth, one by one by one by one, it’s an incredibly slow and uphill climb. We don’t have an effective mechanism for selling our success. We need to better educate our colleagues, we need to tell the community our success stories.

5.
HyperbaricLink: Where do you see things going in the next 3-5 years?
Niezgoda: I suspect that we will see several changes in the field of hyperbaric medicine, some good, some not. I would anticipate that within the next few years several new treatment indications will be accepted. This will be due to current and ongoing research, but also because of continued efforts on the part of the lay public, some of whom are strong advocates for use of HBO for conditions that aren’t on that list of approved indications. One of these indications will relate to the use of HBO for acute hypoxic or ischemic periods, such as for acute ischemic injury to the brain, to the heart, to the lower extremities. I am hopeful there will be an improvement in the way we educate hyperbaric physicians. Newer platforms such as online courses and certification pathways will enhance the care provided to our patients. CMS has already accepted online hyperbaric education, now we just need the professional hyperbaric societies to do the same. Unfortunately, I also see that reimbursement for wound care and hyperbaric services will be cut, which will translate to program closure. Without access to this care, patients will ultimately be negatively impacted, they will suffer with nonhealing wounds and amputations.

6.
HyperbaricLink: If you could teach the world one thing about hyperbaric oxygen therapy, what would it be?
Niezgoda: Good question. Hyperbaric oxygen therapy can achieve some impressive results, some amazing outcomes, and it is complementary or adjunctive to standard care plans. In a limb salvage effort, for example, hyperbaric oxygen can augment surgical and medical care, it can be that bridge, that additional treatment that reverses tissue hypoxia, helps healing, and prevents amputation. So if I could help my surgical colleagues to consider hyperbaric oxygen therapy, rather than defaulting to amputation, that would be a huge lesson. If we could communicate the efficacy of hyperbaric in the care of diabetic foot ulcers, I think we would be doing our patients a great service.

Wednesday, July 18, 2012

Hypoxia and Bends in F-22 Raptor Pilots: USAF and Congressional Inquiry Update

In the wake of new incidents of pilot hypoxia and bends in the F-22 Raptor stealth fighter jet, CNN senior national security producer Mike Mount has filed an excellent report this week on the status of ongoing investigations. Choice quotation:

Last month, the two members of Congress released numbers by the Air Force that showed pilots flying the F-22 Raptor reported illness from oxygen deprivation incidents 10 times as often as pilots of other fighter jets. The data showed Raptor pilots have reported 26.43 hypoxia and hypoxia-like incidents per 100,000 flight hours. While that represents a mere fraction of total flight hours, it is far higher than incidents from other Air Force aircraft, including the A-10, the F-15E and the F-16.

See our May 7 post for the CBS 60 Minutes video that fueled this story. Today the US Air Force keeps 187 Raptors flying from bases in California, Alaska, Virginia, New Mexico, Florida, Nevada, and Hawaii, where the most recent problems occurred.

[Drawing: A.S. Paper Aircraft Lab]

Tuesday, July 17, 2012

One Last Post Re: Success with Hyperbaric Oxygen Therapy for Necrotizing Infections

Before we take a break from this topic, here's one more quick but inspiring story about success with hyperbaric oxygen therapy for deadly soft tissue infections, or flesh-eating disease, sometimes including gas gangrene or bone infections.

Nurse manager Amy Pakes, RN, MS, says Nassau University Medical Center, a NuHealth hospital in East Meadow, New York, sees a dozen cases of necrotizing fasciitis every year:

At Nassau, as soon as a diagnosis is made, the patient receives powerful intravenous antibiotics. Surgical debridement of the infected tissue immediately follows. In addition, hyperbaric oxygen therapy is given to prevent further tissue loss and promote healing.

"We usually take patients right from surgery to the hyperbaric chamber, but they might have to go back for several more surgeries to remove dead tissues and such," Pakes said.

Monday's story on Nurses.com tells the story of one recent case:

"We used all of our resources—our surgical team, hyperbaric team and skilled nursing in the burn center, who did the complicated wound dressings that accompanied the wound care," Pakes said. "The patient was here for almost a month and we were able to save his arm, but it was a team effort."

Eileen Abruzzo, RN, MSN, CIC, director of infection prevention at Winthrop University Hospital in Mineola, New York, was also interviewed for the Nurses.com report.

[Photo: NuHealth website]

Monday, July 16, 2012

HBOT for Necrotizing Fasciitis: South Carolina Mother of Twins Going Home with All Her Limbs

Lana Kuykendall, this year's "other" high-profile victim of necrotizing fasciitis, or flesh-eating disease, underwent extensive hyperbaric oxygen therapy as part of her remarkable recovery at Greenville Memorial Hospital in Greenville, South Carolina. She also suffered with sepsis and endured more than 20 surgical procedures. Now the mother of twins born in May is heading home with all her limbs. This morning the Kuykendalls got the Today Show treatment, too. Click PLAY to watch the video below. Another heartwarming story with a cool HBOT twist.


Visit NBCNews.com for breaking news, world news, and news about the economy

Sunday, July 15, 2012

The Twitter Files: Hyperbaric Chamber Photo from the Penn Medicine Archives

In our daily search for hyperbaric news we enjoyed this 1968 photo from hyperbaric medicine at Penn (University of Pennsylvania in Philadelphia):


Like so many others, Penn Medicine's HyperbaricLink profile could use some work. Twitter is one of the ways we find new and better information about hyperbaric treatment centers on the web.

Friday, July 13, 2012

Hyperbaric Chamber Manufacturers: Meet PBUCH

Thank you, Internet, for bringing a new containerized hyperbaric rescue system to our attention. Add PBUCH S.A., out of Poland, to HyperbaricLink's list of other manufacturers of hyperbaric chambers. PBUCH is short for Przedsiebiorstwo Budowy Urzadzen Chlodniczych, or "Company Plant Engineering," as near as we can tell. Designed to treat decompression sickness (DCS) and for training of submarine crews and undersea divers, the two-compartment system accommodates 10 in treatment and 4 in transfer. We post the video here as a reminder that hyperbaric oxygen therapy has strong roots and many routine uses in military and industrial diving and aviation today. And who doesn't enjoy a product demo so nicely done?



[Video: PBUCH, S.A.]

Thursday, July 12, 2012

Necrotizing Fasciitis Postcript: Aimee Copeland in Rehab, Set to Return Home Next Month

The young woman we wrote about in May has won her life-or-death battle against necrotizing fasciitis or flesh-eating disease. Hyperbaric oxygen therapy played some role—we don't know the details—in Aimee Copeland's recovery from a rare and serious bacterial infection. In June her family released a photo of her enjoying some outdoor time and preparing for rehabilitation. Yesterday they announced she will return home sometime in August. Pretty moving stuff after such a  trying ordeal. Cheers to the Copelands and congratulations to the entire staff at Doctors Hospital in Augusta, Georgia.

[Photo: CNN]

Wednesday, July 11, 2012

Alzheimer's News: Researchers Discover Protective Mutation That Slows Beta Amyloid Buildup

Gina Kolata in the New York Times serves up a fine explanation of an important new Alzheimer's study. The study was published today in Nature [doi:10.1038/nature11283] and conducted by a predominantly Scandinavian group representing Genentech and deCODE genetics, based in Reykjavik, Iceland. The research confirms that the buildup of beta amyloid drives the disease and identifies a rare gene mutation that slows its production and buildup. Finding the genetic key to protecting the brain against protein plaques and tangles may be a real breakthrough in the development of new drugs.

Alzheimer's disease is the seventh leading cause of death in the US, killing nearly 75,000 a year and afflicting 5.3 million.

Recently we updated our Alzheimer's page and found no evidence to support the use of hyperbaric oxygen therapy.

[Image: Nature]

Saturday, July 7, 2012

Sea Turtle Returns to Sea After Successful HBOT for Osteomyelitis

This just in from Florida. How can we not report it? What else but HBOT works for osteomyelitis (bone infection)? How can you not watch? Go, Kahuna, go!

Tuesday, June 26, 2012

New Name, Same Day and Time for Monthly Wound Wire Webcast

Episode 7 of the highly edutaining Wound Rounds LIVE webcast, newly renamed Wound Wire, airs tomorrow 27 June 2012 at 11 AM Central. Co-hosted by Dr Jeffrey A. Niezgoda and Sharon Baranoski, and powered by WebCME, the free webcast streams live on the last Wednesday of every month and covers new technologies, products, and devices, clinical insight, new procedures, and robust literature reviews covering every aspect of wound care.

Friday, June 22, 2012

Hyperbaric Oxygen for Autism: New Rossignol Literature Review Does Not Impress

In May we cheered Ahmad Ghanizadeh's new systematic review of the published clinical evidence on hyperbaric oxygen for autism. Ghanizadeh encouraged further study but found scant evidence to support practice. This month another paper, reviewing the same body of medical literature, and published in the same online open-source journal Medical Gas Research [doi:10.1186/2045-9912-2-16], arrives at a much more optimistic conclusion. The review and analysis was led by Dr Daniel A. Rossignol (pictured right). We are wholly unimpressed. To us this paper smells of wishful thinking and investigator bias. It's almost (but not quite) enough to make us ban Medical Gas Research from our journal club. Read the abstract or download the provisional PDF of the full article and decide for yourself. After exhaustive reading and reflecting, we have at long last completed our update to the HyperbaricLink autism page, now in press. Our writeup and commentary will fully reflect the weakness of the medical literature in this important area of research.

Wednesday, June 20, 2012

Full Program Now Available for Download: 45th UHMS Annual Scientific Meeting

The Undersea and Hyperbaric Medical Society (UHMS) is holding its 45th Annual Scientific Meeting this week, June 21-23, in Phoenix, Arizona. We sorely regret we are not able to attend again this year. Visit the UHMS website to download the Schedule Overview or a PDF of the Full Program including scientific abstracts. Always required reading for everyone interested in evidence-based hyperbaric medicine.

Thursday, June 14, 2012

Freezer Malfunction at Harvard Tissue Bank a Setback for Autism and Other Brain Research

A freezer and alarm failure, causing severe damage to one-third of the frozen brain tissue specimens stored at one Harvard Brain Bank center at McLean Hospital in Belmont, Massachusetts, a collection owned by Autism Speaks, is a real setback to autism research and a wake-up call to other brain banks. The study of donated brains drives some of the most important research into autism, Alzheimer's, traumatic brain injury, and other neurological and psychiatric conditions. We have written before about the Center for the Study of Traumatic Encephalopathy (CSTE), a brain bank affiliated with the Boston University Medical Center and the Sports Legacy Institute at the Bedford Veterans Administration Medical Center in Bedford, Massachusetts. Several groups are investigating the Harvard incident. More in the excellent boston.com story.

[Image: Harvard Brain Tissue Resource Center]

Wednesday, June 13, 2012

Summer Reading List: Young Men and Fire, by Norman Maclean

Across the western US today thousands of firefighters battle 19 active wildfires, on the ground, from the air, under thankfully improving weather conditions. Our thoughts with them. And to our readers once more we recommend Young Men and Fire by Norman Maclean (University of Chicago Press, 1992). It's so much more than a gripping history of the 1949 Mann Gulch tragedy, in which a crew of elite smokejumpers got caught in a blowup. It's also a detailed explanation of how wildfires work, a fact-filled commentary on what the firefighting community learned and how it changed its approach to fighting wildfires in the last half century, and a personal memoir about living and dying. You won't find much better nonfiction prose anywhere. Maclean also wrote A River Runs Through It and Other Stories. We suggest Young Men and Fire as Further Reading on our smoke inhalation page. We recommend it again here for what's shaping up to be another memorable season of western fires.

Tuesday, June 12, 2012

Hyperbaric Oxygen for Inflammatory Bowel Disease (IBD): Systematic Review of the Medical Literature

We are loath to recommend the work of such a controversial figure as Dr Daniel Rossignol. But his new systematic review and analysis of the medical literature on hyperbaric oxygen therapy (HBOT) for inflammatory bowel disease is very helpful indeed.

Inflammatory bowel disease (IBD), the chronic inflammation of all or part of the digestive tract, includes Crohn's disease and ulcerative colitis. Rossignol's review includes both human and animal models, touches on some of the physiologic mechanisms that may (or may not) be involved, and finds the published clinical evidence for HBOT stronger for Crohn's than for ulcerative colitis:

In the studies of Crohn's disease, 78% of treated patients had an improvement with HBOT at a pressure ranging from 2.0 to 2.8 ATA. In the studies of ulcerative colitis, all treated patients showed improvements with a pressure delivered at 2.0 ATA. These studies suggest that a higher pressure may be needed to achieve these improvements. However, because none of these studies utilized a lower pressure of HBOT, it is not known if a lower pressure or oxygen level would be beneficial in IBD. However, some investigators have reported improvements in GI function in some children with autism using HBOT at 1.3 to 1.5 ATA [117,118]. Furthermore, previous studies have reported improvements in certain neurological conditions using hyperbaric treatment at lower pressures and/or oxygen levels [119-122]. Additional studies using HBOT at varying oxygen concentrations and atmospheric pressures would be helpful in determining optimal treatment protocols.

This self-serving argument and the mild HBOT studies cited, 117-122, including Rossignol's own widely discredited autism study, significantly weaken an otherwise fine review of the medical literature on this important topic.

[Image: findingDulcinea]

Thursday, June 7, 2012

Diabetic Ulcers without Optimal Glycemic Control: New Study Concludes HBOT Should Not Be Delayed

Physicians treating wounds in patients with diabetes often delay hyperbaric oxygen therapy until the patient has attained optimal blood sugar levels. A new multicenter, prospective cohort study, presented 24 May 2012 in Philadelphia at the annual meeting of the American Association of Clinical Endocrinoligists, suggests that, in patients with diabetic ulcers of the lower extremities, the success of hyperbaric oxygen therapy is not affected by pretreatment glycemic control.

Here's the complete abstract from the AACE 2012 Abstract Book:

GLYCEMIC CONTROL AT INITIATION OF HYPERBARIC OXYGEN THERAPY DOES NOT AFFECT DIABETIC LOWER EXTREMITY WOUND HEALING
Owaise Mansuri, MD, Parkash Bakhtiani, MBBS, Abhijeet Yadav, Chima Osuoha, Patricia Knight, Robert McLafferty, Michael Jakoby, IV, MD
 

Objective: Diabetic lower extremity ulcers are a major cause of disability and mortality, accounting for approximately two-thirds of all non-traumatic amputations performed in the United States. Hyperbaric oxygen (HBO) is increasingly used as an adjunct to antibiotics, debridement, and revascularization for therapy of chronic, non-healing wounds associated with diabetes mellitus. We investigated whether glycemic control at time of HBO therapy measured by hemoglobin A1c (HbA1c) has a significant impact on diabetic wound healing. Methods: A multi-center, prospective cohort study assessing lower extremity wound healing rates among adult patients with diabetes mellitus treated with HBO was conducted at the Regional Wound Care Center in Springfield, IL and University Medical Center Hyperbaric Oxygen Center and Burn Care Unit in Las Vegas, NV. Patients underwent 20 sessions of HBO over the course of one month, and ulcer size (surface area and depth) and location were recorded at each visit. Transcutaneous oxygen pressures (TcPO2) were measured during each session. HbA1c was measured at first and last HBO treatments from capillary blood specimens using a Siemens DCA Vantage A1c Analyzer. Patient characteristics including age, gender, weight, type and duration of diabetes mellitus, current diabetes treatment regimen, hypertension, peripheral artery disease (PAD), tobacco use, ulcer duration, and additional wound care therapies (e.g. debridement, platelet derived growth factor) were determined. Results: Complete data were collected for 22 patients who were included in the study analysis and divided into two groups based on pre-HBO HbA1c. Patients in the “controlled diabetes” group had HbA1c < 7.5%, and patients in the “uncontrolled diabetes” group had HbA1c ≥ 7.5%. Mean HbA1c in the “controlled diabetes” group (6.5 ± 0.8%, N=12) was significantly lower (P < 0.001) than in the “uncontrolled diabetes” group (8.8 ± 1.4%, N=10). Both groups were well matched across all other recorded characteristics. Wound volume was reduced by 65 ± 29% in the “controlled diabetes” group and 71 ± 30% in the “uncontrolled diabetes” group (P = 0.60). Wound healing was also unaffected by presence or absence of PAD, hypertension, tobacco use, weight, duration of diabetes, or ulcer duration. Discussion: This study demonstrates that diabetic lower extremity wound response to HBO treatment is unaffected by pre-treatment glycemic control and several other clinical factors that may adversely impact wound healing. Conclusion: HBO treatment should not be delayed if glycemic control is suboptimal at time that therapy is prescribed.

Previous studies have shown that hyperglycemia inhibits wound healing. Here there was no significant difference between the controlled and uncontrolled groups. Why? Lead author Mansuri, in widespread press coverage of the findings, has said, "We suspect that the effect of hyperbaric oxygen therapy was potent enough to overcome the negative effect of hyperglycemia." We're eager to learn more from any wound care and hyperbaric medical experts who may wish to comment.

Wednesday, June 6, 2012

In the News: Hyperbaric Oxygen Therapy for Leber Hereditary Optic Neuropathy (LHON)?

Today the National Hyperbaric Centre of Dublin, Ireland, reports success in using hyperbaric oxygen therapy (HBOT) to save the eyesight of a young man with Leber hereditary optic neuropathy (LHON), a mitochondrial disease that usually causes a loss of central vision within two to eight weeks. Eric Lokko, pictured here, began losing his eyesight at age 12, started HBOT at 14, and can see well enough at 16 to qualify for a driver's license. More of this story on Independent.ie.

Cheers to Eric, his family, and his clinical team, and thanks for inspiring us to look into the medical literature on this subject. Hyperbaric oxygen is now indicated for the treatment of central retinal artery occlusion (CRAO), a kind of stroke of the eye, a vascular event requiring speedy attention. Proper treatment in the first 24 hours is critical. Until today's news we had not heard of any longer-term use of hyperbaric oxygen to preserve or restore eyesight or prevent blindness.

About HBOT for Leber hereditary optic neuropathy, the International Foundation for Optic Nerve Disease (IFOND) says:

The sparse negative anectodal evidence of Hyperbaric Oxygen Therapy [HBO] treatment specifically in LHON is not encouraging. This is not currently a line of active research in LHON. HBO has been suggested as a treatment by delivering increased levels of oxygen to the affected nerve cell during its "starvation" period, or period of onset of blindness. A counter argument is that too much oxygen may be toxic in the context of poor cell antioxidant functioning. Oxygen toxicity to the eye is a known problem in premature babies on oxygen. There has been some success, however, using HBO with with other nerve diseases.

This paragraph does not sound like the work of someone who has made a serious study of the hyperbaric medical literature. A quick search for "optic AND neuropathy AND hyperbaric" yields 8 entries in the Rubicon Research Repository and 33 papers on PubMed. We better get reading.

[Photo: Independent.ie]

Tuesday, June 5, 2012

Johns Hopkins Medicine: About as Good as Online HBOT Info Gets (and That's Not a Compliment)

Should you somehow manage to find the Hyperbaric Oxygen Therapy page, somewhere under Dermatology, in the Johns Hopkins online Health Library, you will be rewarded with a pretty okay overview. You will learn that HBOT helps wound healing, prevents "reperfusion injury" (nice), blocks harmful bacteria, strengthens the immune system, and encourages the formation of new connective tissue and skin cells. You will also get a quick history of hyperbaric medicine (why?) and blurbs about clinical indications, mechanisms, chamber types, precautions, and misuses. As one would expect, this august medical institution also takes a stand for hospital-based HBOT facilities staffed by trained and certified medical personnel.

Brilliant. Until the last paragraph, under "Misuses of HBOT":

In addition, some chiropractors and clinics use portable fabric HBOT chambers, the routine use of which, experts say, poses a serious fire and explosion hazard. Although no fire fatalities involving HBOT in a hospital setting have been reported since 1967, portable chambers have been implicated recently in several deaths after a unit caught on fire. 

Wrong. The doubly fatal 2009 fire at Lauderdale-by-the-Sea, Florida, involved a 40-year-old hard chamber. The other recent fatal incident, earlier this year in Ocala, Florida, involved a large chamber used to treat horses. Portable fabric bags—we won't call them hyperbaric chambers—raise all sorts of questions about therapeutic efficacy and medical fraud and quackery, but they do not pose a "serious fire and explosion hazard" if used as intended. We feel odd defending chiropractors and bag clinics. Those are just the facts.

Last month we wrote the Johns Hopkins webmaster to correct this misinformation but have not yet received a reply.

HyperbaricLink lists the wound healing center at the Johns Hopkins Bay View Medical Center, and from there, with just a click or two, to anywhere on our website, you will find more complete and more accurate information about hyperbaric oxygen therapy. That's why we're in business.

Monday, June 4, 2012

UHMS Accredits Hyperbaric Medicine at Eisenhower Army Medical Center, Fort Gordon, Georgia

The Hyperbaric Medicine Service at Dwight David Eisenhower Army Medical Center in Fort Gordon, Georgia, has received accreditation from the Undersea and Hyperbaric Medical Society (UHMS). Fort Gordon is home to the US Army Signal Corp. The military-only center is not open to the public. About UHMS accreditation, medical director Michael Madsen, MD, said it:

... signifies Eisenhower Army Medical Center’s commitment to patient safety and upholding the highest performance standards when treating patients with hyperbaric oxygen therapy.

Read the announcement in The Fort Gordon Signal. Learn more about facility accreditation in our UHMS profile and on the UHMS website.

[Photo: Eisenhower Army Medical Center website]

Thursday, May 31, 2012

Multibillion-dollar Losses at JPMorgan Linked to Key Executive's Struggle with Lyme Disease

When we read "JPMorgan's $6 Billion Case of Lyme Disease" in Forbes we thought maybe it was an Onion headline. But, sure enough, bank insiders and Wall Street traders have placed part of the blame for the massive blunder on the health problems of one top executive. Ina Drew, pictured right, started missing work after she contracted Lyme disease in 2010. Apparently she played a key role in keeping the peace and refereeing shouting matches in the chief investment office, and her frequent absence threw the team into chaos.

Drew resigned earlier this month. She was the bank's fourth-highest-paid officer.

Spend one of your free visits on the fascinating New York Times article that broke the story. You may also wish to join tick and Lyme disease experts in a surprisingly informative discussion with Science Friday. More about hyperbaric oxygen therapy for Lyme disease on HyperbaricLink and in our previous blogposts.

We are told to expect an unusually active tick season after this year's mild winter. No comment about other, possibly human, pests and parasites that may spoil our summer.

[Photo: JPMorgan via Bloomberg News and New York Times]

Wednesday, May 30, 2012

First Look: Hennepin County Medical Center Replacement Hyperbaric Facility Set to Open in June

The local media is buzzing about the new hyperbaric oxygen treatment center set to open in June at Hennepin County Medical Center (HCMC) in Minneapolis, Minnesota. The TV spot below features a patient story that adds the human element to HCMC's long struggle to build this impressive new facility, designed and constructed by Fink Engineering. We also enjoyed last week's story in the StarTribune. Medical director Cheryl Adkinson, MD, calls the $10.9 million facility "the most advanced chamber anywhere in the world at the moment," and she's probably right.

Tuesday, May 29, 2012

Memorial Day Reflections on Traumatic Brain Injury and the March 11 Massacre in Panjwei, Afghanistan

This long weekend we, like all Americans, remembered our fallen war dead. But we could not help also thinking about the atrocity of March, when Army staff sergeant Robert Bales murdered 17 Afghan civilians in their homes in the middle of the night. Speculations of traumatic brain injury (TBI) and posttraumatic stress disorder (PTSD) hit the press even before Bales was identified as the alleged killer.

Of all the coverage since, three pieces struck us as thoughtful and perhaps worth your attention:

Katie Drummond, in the Danger Room at Wired, lays out some of the known and suspected connections between TBIs, PTSD, and violent episodes.

Sharon Weinberger, writing in Nature, focuses on the challenges ahead for Bates's legal team and asks: "Can a traumatic injury explain a killing spree?"

Lena Groeger, for ProPublica, finds serious doubts surrounding the $42 million Automated Neuropsychological Assessment Metrics (ANAM), a 20-minute computer test many soldiers take before redeployment.

The common theme here, and in our sobering reflections, is the need for better diagnosis and more effective intervention to help soldiers who may suffer a lifetime with these conditions. Stay tuned to HyperbaricLink for more news on the state of the clinical evidence on hyperbaric oxygen therapy for TBI (and PTSD).

[Photo: Wikimedia]

Tuesday, May 22, 2012

Necrotizing Infections: National Story Generates Some Local Interest in Omaha

Widespread coverage of the Georgia woman battling a necrotizing infection in an Augusta hospital has led health journalists across the country in search of the local angle. Of most interest: Doctors report an unusually high number of cases recently at Nebraska Medical Center in Omaha. Hyperbaric medical director Dr Jeff Cooper said his center has treated six patients with necrotizing fasciitis, or soft tissue infections caused by flesh-eating bacteria, in just the last month or so. He cannot account for the sharp increase but briefly explained to Omaha.com how hyperbaric oxygen works against the disease:

Cooper said hyperbaric oxygen therapy is an important part of treating the disease. “It forces oxygen into areas that aren't getting adequate oxygen because of the tissue damage and swelling,” he said. “This revives the immune system locally and causes the antibiotics to work more effectively.”

Today the medical center is holding a press conference on the subject. More on the web at WOWT Channel 6 and the Omaha World-Herald.

[Photo: Nebraska Medical Center]

Monday, May 21, 2012

A Podiatrist Speaks Against Podiatrists Supervising Hyperbaric Oxygen Therapy

A leading podiatric physician and regular Podiatry Today blogger last week spoke up against Doctors of Podiatric Medicine (DPMs) monitoring patients receiving hyperbaric oxygen therapy (HBOT). Citing state law in his home Indiana and discussions with his Healogics wound center colleagues, DeHeer concludes:

Despite being a proud member of the podiatric profession, I feel that until we have a combined MD-DPM degree, it is in our patients’ best interest to have our allopathic and osteopathic colleagues monitor HBOT patients.

In other words, as so often we have commented here and on HyperbaricLink:

Hyperbaric oxygen is serious medicine that should always be prescribed by a physician. Treatments should always be supervised by a qualified hyperbaric specialist (MD or DO) assisted by a certified hyperbaric technician (CHT).

Podiatric physicians play a vital and sometimes leading role in the care of people with diabetic ulcers and other wounds and injuries of the foot. Hats off to Dr DeHeer for working to clarify his profession's role in hyperbaric medicine.

Now we're curious. How does your hyperbaric treatment center involve podiatrists in patient care?

[Image: Podiatry Today DPM Blogs]

Sunday, May 20, 2012

Hyperbaric Oxygen for Necrotizing Fasciitis: Georgia Woman Loses Limbs and Fights for Life

Our thoughts today with Aimee Copeland, the 24-year-old University of West Georgia graduate student who is fighting a very public battle against necrotizing fasciitis at Doctors Hospital in Augusta. Copeland suffered a deep gash to her leg in a zip-lining accident on May 1. By May 4 the wound had become infected with the rare flesh-eating bacterium Aeromonas hydrophila. She was rushed to the hospital, where doctors amputated most of her left leg and worked to stop the potentially deadly infection from spreading. Hyperbaric oxygen therapy, begun last Wednesday, failed to salvage her remaining foot and both hands. Copeland remains in critical condition.

In the treatment of necrotizing fasciitis, hyperbaric oxygen inhibits bacteria from replicating, spreading, and releasing damaging toxins. It may also boost the effect of antibiotics, enhance the body’s natural defenses against flesh-eating bacteria, and help resolve or delay the onset of sepsis, a deadly blood poisoning. From the commentary section of our necrotizing infections page:

Hyperbaric oxygen can be a potent bactericide and also treats the hypoxia at the root of soft tissue necrosis. One analysis [Undersea Hyperb. Med. 2005 Nov-Dec; 32(6):437-43] showed significantly fewer deaths and amputations with HBOT. As the [UHMS] writeup concludes: “With such strong case series evidence of reductions in morbidity and mortality for necrotizing fasciitis and the subset of Fournier's Gangrene, it is difficult to envision ever seeing a controlled, double-blinded study of hyperbaric oxygen therapy.” In other words, considering the deadly seriousness of necrotizing infection and the demonstrated effectiveness of HBOT, withholding treatment from a control group for comparative study would not be medically or ethically acceptable. As antibiotics and other traditional weapons against these worrisome microscopic invaders begin to weaken, HBOT provides a vital backstop.

Keep track of Aimee's condition on Facebook.

[Photo: Copeland family Facebook page]

Friday, May 18, 2012

Headstrong: Postshow Brain Injury Discussion (Part 2)

At long last we bring you Part 2 of Ivan Oransky's postshow discussion May 2 with neuropsychologist Dr Jill Brooks and ESPN senior writer Peter Keating. The stage play Headstrong runs through May 27 at the Ensemble Studio Theater in New York City.

Part 2 (29:03)



Hat tip: Rich Kelley (@rpmkel)

Thursday, May 17, 2012

Hyperbaric Oxygen and Type 1 Diabetes: New Animal Study Suggests Preventive Effect

When HyperbaricLink talks diabetes we're usually talking diabetic ulcers. But we note with great interest a promising new paper published online last week in the American Diabetes Association journal Diabetes, in which scientists at the University of Miami say they used hyperbaric oxygen to prevent or slow the progression of Type 1 diabetes in mice.

Our first question is, How does hyperbaric oxygen work? From the abstract:

HOT reduces autoimmune diabetes incidence in NOD mice via increased resting T cells and reduced activation of DCs with preservation of β-cell mass resulting from decreased apoptosis and increased proliferation.

We won't pretend to understand much of this beyond the given abbreviations: hyperbaric oxygen therapy (HOT), non-obese diabetic (NOD), and dendritic cells (DC). But we do know how difficult it can be to translate findings from animal laboratory experiments to human clinical studies. And we're not quite sure how physicians would know how to select patients and whether or when to use hyperbaric oxygen. A neat summary of the paper in HealthDay raises these and other questions.

That hyperbaric oxygen affects diabetes is not news to many researchers. Back in July 2010 we noted a paper in the Polish Journal of Endocrinology concluding "HBOT was shown to have beneficial effects on atherosclerosis and glycaemic control" in a study of 28 diabetes patients with foot ulcers.

The Miami study used 100% oxygen at 2.0 atmospheres absolute (ATA) and the Polish study at 2.4 ATA. Of course such subtleties will not stop every inflatable bag dealer from claiming this evidence as their own. Let the buyer beware.

For the evidence-based hyperbaric medical community, this is an altogether fascinating area of hyperbaric medical research. We have reached out to the Miami research team and eagerly await further studies.

Monday, May 14, 2012

Autism Postscript: State of the Science on Causes and Mechanisms

Friday we lamented the lack of any clinical evidence to support the use of hyperbaric oxygen therapy in children with autism. Yet the science in this field continues to fascinate. Later that night we enjoyed Charlie Rose's enlightening conversation with some leading autism experts: Eric Kandel of Columbia University, Gerald Fischbach of the Simons Foundation, Uta Frith of University College London, Matthew State of Yale University, and Alison Singer of the Autism Science Foundation. Part of Rose's ongoing Brain Series, the discussion touched on the latest findings and prevailing theories about the (especially) genetic causes and mechanisms of autism spectrum disorders.

Friday, May 11, 2012

Hyperbaric Oxygen for Autism: New Systematic Review of the Medical Literature

For anyone interested in the use of hyperbaric oxygen to treat children with autism, we note the publication today of a simple but helpful systematic review in the online open-access journal Medical Gas Research, by Ahmad Ghanizadeh, Director of Research Center for Psychiatry and Behavioral Sciences at Shiraz University of Medical Sciences in Iran. From today's abstract:
The electronically [sic] search resulted in 18 title of publications. Two studies were randomized, double-blind, controlled-clinical trials. While some uncontrolled and controlled studies suggested that HBO therapy is effective for the treatment of autism, these promising effects are not replicated. Therefore, sham-controlled studies with rigorous methodology are required to be conducted in order to provide scientific evidence-based HBO therapy for autism treatment.
Ghanizadeh's findings support the prevailing view of the evidence-based medical community. Even the two supposed randomized controlled trials (RCTs) he identifies do not, in our view, support the practice, except in the course of clinical investigation. Nor do the eight studies listed on ClinicalTrials.gov show much promise of answering the important questions. Look for a quick update of our autism page in the weeks ahead.

Thursday, May 10, 2012

Wound Care Advantage: Distinguishing Its Approach and Model from the New Healogics

Soon after the launch of Healogics, with some 540 wound care and hyperbaric centers across the US, comes the first open letter to the community from a key competitor, Wound Care Advantage. Founder and CEO Mike Comer writes:
Granted our approach and model differs from the new Healogics. Wound Care Advantage is focused on turning around existing centers that are doing poorly and helping hospitals take over their own programs in order to have more control and retain more revenue.... I still feel a focused approach on each hospital is key. These hospitals also need a strategy for their wound center to retain as much revenue as possible.
Read the entire post on the Wound Care Advantage blog. We expect to see a lot more competitive positioning against, around, and alongside Healogics in the months and years ahead. We also expect a steady expansion of the provider market to serve a steadily expanding and rapidly aging patient population whose wound care needs remain seriously underserved today.

Wednesday, May 9, 2012

USC Catalina Hyperbaric Chamber Featured in Scientific American Blog

For the last month the "Expeditions" blog on the Scientific American website has run an excellent series on the University of Southern California Dornsife Scientific Research Diving program. The May 4 installment covers the USC Catalina Hyperbaric Chamber. Written by dive safety officer Gerry Smith, the short piece nicely summarizes the center's important role in treating recreational and scientific divers and others who suffer decompression sickness and air or gas embolism. We've written before about USC Catalina but didn't know the center is funded equally by the Los Angeles County Medical Alert Center and the local diving community and staffed 24/7 by a full-time director, a part-time technician, and some 70 volunteers.

[Photo: Karl Huggins]

Tuesday, May 8, 2012

Banner Boswell Medical Center in Sun City, Arizona, Adds Third Hyperbaric Chamber

The growing hyperbaric oxygen therapy center at Boswell Banner Medical Center in Sun City, Arizona, helped this man with bladder spasms caused by delayed radiation injury and caught the attention of this local TV health reporter. The center will host a community open house to show off its new chamber 8a to 11a on Wednesday 16 May.

Monday, May 7, 2012

Hyperbaric Oxygen Figures in 60 Minutes Exposé on US Air Force's F-22 Raptor Fighter Jet

Last night 60 Minutes interviewed two pilots who refuse to fly the US Air Force's F-22 fighter jet after experiencing serious health problems, including decompression sickness, vertigo, and a chronic "Raptor cough," apparently caused by hypoxia, or lack of oxygen. One of the pilots reports he had to be treated in a hyperbaric oxygen chamber after one test flight. Faulty emergency oxygen controls, charcoal air filters, and other engineering failures have plagued the new aircraft throughout production and testing. Fortunately, the USAF operates some of the best hyperbaric medicine facilities in the world.

Thursday, May 3, 2012

Headstrong: Postshow Brain Injury Discussion (Part 1) and Extended Run

Since this morning's post the Ensemble Studio Theatre production of the stage play Headstrong has been extended through May 27. As advertised, we bring you these videos of Ivan Oransky's postshow discussion last evening with neuropsychologist Dr Jill Brooks and ESPN senior writer Peter Keating.

Part 1 (29:10)



Hat tip: Rich Kelley (@rpmkel)

NFL Legend Junior Seau: Apparent Suicide, Possible Brain Injury, Stirring Tragedy

When football great Junior Seau was found dead at his home yesterday, from a gunshot wound to the chest, his family and the police and reporters and sportswriters everywhere made the logical leap from concussion to chronic traumatic encephalopathy (CTE) to depression to suicide. All you have to say is "Duerson." Select stories here, here, and here, along with our previous coverage.

But just last Friday, our favorite science radio show aired a thought-provoking segment about how very much we still don't know about athletes and concussion. University of Michigan sports neurologist Jeffrey S. Kutcher, MD, cautioned listeners to follow the clinical evidence, which does not explain how repeated traumatic brain injury (TBI) might cause problems with brain function later in life. The discussion was inspired by a new stage play, Headstrong, running at the Ensemble Studio Theatre in New York City through May 13. How we wish we could have attended last night's performance, with a scientific postdiscussion moderated by Ivan Oransky of Reuters Health and Retraction Watch. Video posted here when available.

[Image: Purdue University/Thomas Talavage]

Wednesday, May 2, 2012

Hyperbaric Physician and Tech Charged with Manslaughter in 2009 Florida Chamber Fire

Three years after the first fatal hyperbaric chamber fire in the US, on 1 May 2009 at Neubauer Hyperbaric Neurologic Center, formerly Ocean Hyperbaric Neurologic Center, in Lauderdale-by-the-Sea, Florida, medical director Dr George Daviglus, 81, and hyperbaric technologist Lance Bark, 51, have been arrested and charged with aggravated manslaughter. The fire killed an Italian boy, Francesco Martinisi, 4, and his grandmother, Vicenza Pesce, 62.

Broward County Sheriff's Detective Frank Ilarraza, pictured above, spoke April 25 about the "gross negligence" revealed by his investigation. The South Florida Sun Sentinel summarizes the arrest report:
  • Static electricity caused a spark that ignited dust inside the chamber.
  • Neither the chamber hull nor Pesce and Francesco were properly grounded to prevent static electric shocks.
  • Pesce's and Francesco's garments included metal and flammable synthetic fabrics, polymers, plastics, and ink.
  • Baby wipes containing alcohol and other combustible chemicals were inside the chamber.
  • No operator was present.
  • The chamber intercom system was not working.
  • Operators did not follow emergency procedures for 30-second chamber depressurization.
  • The chamber was over 40 years old and had been improperly rewired.
Click here to download the 11-page [PDF] complaint affidavit.

State Fire Marshal's Office Detective Edwin Tapanes called for stricter regulations of hyperbaric facilities across Florida. All across the country, physicians and technicians will be studying these findings and redoubling their efforts to ensure the safe delivery of hyperbaric oxygen therapy. Patients and families should feel confident in asking facility and equipment operators about safety procedures, regulatory compliance, and equipment certifications. More about chamber types and safety here.

[Image: Sun Sentinel video capture]

Tuesday, May 1, 2012

They Call It Healogics

The company formed by the merger of National Healing Corporation and Diversified Clinical Services now has a name: Healogics. The companies agreed to merge last September and announced the new identity on April 19 at the spring meeting of the Symposium on Advanced Wound Care (SAWC) and Wound Healing Society (WHS). Based in Jacksonville, Florida, Healogics is the largest provider of advanced wound care, managing more than 500 centers in more than 10% of US hospitals.

Click here to download [PDF] the full news release, in which chief medical officer Robert Warriner, MD, said:
The rise in obesity and the growth of the aging population results in a higher number of chronic wounds. It is imperative that we educate medical professionals, patients, and families about the advanced treatments available to promote healing.
Hear! Hear!

Thursday, March 22, 2012

UHMS Accredits Hyperbaric Medicine at McKay-Dee Hospital Center in Ogden, Utah

The Wound Care and Hyperbaric Center at McKay-Dee Hospital Center in Ogden, Utah, has received accreditation from the Undersea and Hyperbaric Medical Society (UHMS). The hospital-based facility is part of the Intermountain Healthcare system. Learn more about facility accreditation in our UHMS profile and on the UHMS website.

[Photo: McKay-Dee Hospital Center website]

Wednesday, March 21, 2012

UHMS Accredits Hyperbaric Medicine at Jordan Valley Medical Center in West Jordan, Utah

The Hyperbaric and Wound Care Center at Jordan Valley Medical Center in West Jordan, Utah, has received accreditation from the Undersea and Hyperbaric Medical Society (UHMS). The 4,500-square-foot outpatient medical facility opened in 2010. Learn more about facility accreditation in our UHMS profile and on the UHMS website.

[Photo: Jordan Valley Medical Center website]